In hemochromatosis there is typically an increased uptake of iron in the small intestine despite already adequate iron storage. This leads to iron deposition in the liver, pancreas, joints,myocardium and hypophysis. There is both an inherited and
a transfusion-induced type of hemochromatosis. Typical symptoms include diabetes, arthralgias, cardiac insufficiency and hypogonadism. To avoid permanent organic deficiency it is important to diagnose the inherited type.Whereas blood examination
is able to hint at the possibility of hemochromatosis, a liver biopsy with increased iron
storage in hepatocytes establishes the diagnosis.
In MRI the increased iron content can be demonstrated by calculation of the T2 relaxation time. This allows diagnosis as well as follow-up un-der therapy to be assessed. Patients suffering from untreated hemochromatosis typically develop liver
cirrhosis and are at high risk of HCC development. Consequently, regular imaging studies should be initiated.
(tumor of the liver ) Histology of hepatic parenchyma affected by
hemochromatosis. Hemosiderin is predominantly accumulated in
periportal parenchymal cells, which is in contrast to siderosis of
the liver in which iron is stored predominantly in Kupffer cells