(a) MRI of liver and in-phase (b) and out-of-phase (c) T1-weighted GRE images demonstrating iron deposition in both the liver and the spleen. The coronal T2-weighted image shows abnormal low signal intensity in the liver and spleen.
(a). MRI of liver Normally, the spleen is higher in signal intensity than the liver, and both liver and spleen should be significantly higher in signal intensity than paraspinal skeletal muscle (Refer to Fig. 1 and 2 for examples of normal liver signals). The in-phase T1-weighted GRE image.
(b) MRI of liver shows a marked drop in signal intensity throughout the liver and the spleen, in contrast to the out-of-phase image
(c) MRI of liver in contrast to paraspinal muscle. These images show changes resulting from T2* effects of paramagnetic iron accumulation