Ultrasound images Leukaemia of spleen

Leukaemia (literally meaning ‘white blood’, from the Greek) is characterized by an increased number of malignant white blood cells. Unlike lymphoma,
which affects the lymphatic system, leukaemia affects the circulation. There are two main types, myeloid and lymphoid, both of which can be either acute or chronic.
Patients present with fatigue, anaemia, recurrent infections and a tendency to bleed internally. The patient’s inability to overcome infections may eventually lead to death. Chemotherapy is successful in curing acute lymphoblastic leukaemia in approximately half the patients, and may induce remission in others. The long-term prognosis is poor for other types of leukaemia, although patients may survive for 10 years or more with the slow-growing chronic lymphocytic leukaemia Leukaemia produces diffuse splenic enlargement, but rarely with any change in echogenicity. Abdominal lymphadenopathy may also be present.

The bone marrow becomes infiltrated with malignant cells which cause the blood to have increasing levels of immature blood cells.
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ultrasound images Solitary hypoechoic splenic metastasis from melanoma.
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ultrasound images Metastasic deposits (arrows) in a patient
with gastric carcinoma.
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Ultrasound images Disseminated metastases from breast carcinoma affect the spleen, giving it a coarse texture
and lobulated outline.
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