Ultrasound of CHOLELITHIASIS
Ultrasound is an essential 
first-line investigation in suspected gallbladder and biliary duct disease. It 
is highly sensitive, accurate 
and comparatively cheap and is the imaging modality of choice.1 
Gallbladder pathology is common and is 
asymptomatic in over 13% of the population.
CHOLELITHIASIS
The most commonly and 
reliably identified gallbladder pathology is that of gallstones (see 
Table 3.1). More than 10% of the 
population of the UK have gallstones. Many of these are asymptomatic, which is an important point 
to remember. When Gallstones—clinical features Often asymptomatic
Biliary colic—RUQ pain, 
fatty intolerance +ve ultrasound Murphy’s sign (if inflammation is 
present) Recurring (RUQ) pain in 
chronic cholecystitis Jaundice (depending on degree of obstruction) Fluctuating 
fever (if infection is present RUQ=right upper 
quadrant.
scanning a patient with 
abdominal pain it should not automatically be assumed that, when 
gallstones are present, they are 
responsible for the pain. It is not uncommon to find further pathology in 
the presence of gallstones and a 
comprehensive upperabdominal survey should always be carried out. Gallstones are associated 
with a number of conditions. They occur when the normal ratio of components making up the 
bile is altered, most commonly when there is increased secretion of 
cholesterol
in the bile. Conditions 
which are associated with increased cholesterol secretion, and therefore the 
formation of cholesterol stones, include obesity, diabetes, pregnancy and 
oestrogen therapy. The incidence of stones also rises with age, probably because 
the bile flow slows down. An increased secretion of bilirubin in the bile, 
as in patients with cirrhosis 
for example, is associated with pigment (black or brown) stones.
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