Bone lesions can be differentiated by several features, including age, number, morphology, and location. For cystic lesions located in the epiphysis, the mnemonic
CAGGIE is useful to recall the most common possibilities:
| Disease | Notes |
| C | Chondroblastoma | Rare, can have fluid-fluid level |
| A | Aneurysmal bone cyst | Can also have fluid-fluid level |
| G | Giant cell tumor | Only occurs after physeal closure (age>20), fluid-fluid level |
| G | Geode | aka subchondral cyst (benign) |
| I | Infection |
|
| E | Eosinophilic granuloma
Enchondroma |
|
Metastatic disease should also be considered, depending on the clinical context.
References:
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