Post Varicella Demyelination-MRI
Symptoms usually follow 1-20 days of viral infection. Age group affected commonly is between 1-20 years. The hallmark of the disease is acute development of neurological signs accompanied by complaints of headache, fever, and alteration of sensorium.
Cerebellar symptoms are very strongly associated with post varicella ADEM. The lesions usually involve subcortical white matter and deep-seated grey matter including basal ganglia, thalamus and cerebellum The pathological features of ADEM are perivenular inflammation and demyelination due to autoimmune mediated response to CNS myelin. ADEM is usually a self-remitting disease. Approximately 70% of the patients show complete recovery. Mild cognitive deficit remains in children who have otherwise recovered clinically and radiologically. Ref: Indian pediatrics 2005
Cerebellar symptoms are very strongly associated with post varicella ADEM. The lesions usually involve subcortical white matter and deep-seated grey matter including basal ganglia, thalamus and cerebellum The pathological features of ADEM are perivenular inflammation and demyelination due to autoimmune mediated response to CNS myelin. ADEM is usually a self-remitting disease. Approximately 70% of the patients show complete recovery. Mild cognitive deficit remains in children who have otherwise recovered clinically and radiologically. Ref: Indian pediatrics 2005
Case by Dr MGK Murthy, Sr Consultant Radiologist
Prime Telerad providers Pvt Ltd
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