Osteosclerosis: Differential Diagnosis #7
Osteosclerosis, or general increased density in the skeletal bones, is a relatively rare diagnosis. However, when it occurs, the entities that cause it are important to recognize. One way to recall the various causes for osteosclerosis is the mnemonic Regular Sex Makes Occasional Perversions Much More Pleasurable And Fun (Don't look at me - I didn't make it up):
Other possible causes include osteopoikilosis, osteopathia striata, hypothyroidism, and melorrheostosis. You can thank Brant & Helms for the mnemonic.
| Disease | Notes | |
| R - Regular | Renal osteodystrophy | |
| S - Sex | Sickle cell disease | |
| M - Makes | Myelofibrosis | |
| O - Occasional | Osteopetrosis | aka Albers-Schonberg disease present with fractures, splenomegaly |
| P - Perversions | Pynknodysostosis | aka Toulouse-Latrec syndrome associated with acro-osteolysis and Wormian bones |
| M - Much | Mastocytosis | |
| M - More | Metastatic carcinoma | Breast, prostate, lymphoma/leukemia |
| P - Pleasurable | Paget's disease | |
| A - And | Athletes | |
| F - Fun | Fluorosis |
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| Pynknodysostosis Source: Radiopaedia |
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