Today's Daily Diff is about
stippled epiphyses. In these cases, the epiphyses appear to have multiple, small, round densities within them. If you have a hard time remembering the diverse causes, don't worry - just take a
WHACK at it:
| Disease | Notes |
| W | Warfarin |
- maternal use during pregnancy
|
| H | Hypothyroidism
Hans Zellweger syndrome |
- Hypothyroidism / cretinism is a much more common cause
- Hans Zellweger aka cerebro-hepato-renal syndrome
- rare leukodystrophy
- punctata in patella
|
| A | Alcohol |
- maternal use during pregnancy
|
| C | Chondrodysplasia punctata congenita |
- multiple variants exist (ex: Conradi–Hünermann syndrome)
- causes growth problems
|
| K | vitamin K deficiencies |
- Vitamin K reductase deficiency
- ex: Warfarin use
|
Admittedly, the mnemonic is a bit of a stretch, but essentially the diagnoses are either due to syndromes or factors that affect vitamin K metabolism.
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